Showing Posts From
Science
-
Sukhi Singh - 24 Apr, 2026
Antibody Discovery
Antibody discovery is stuck in a reproducibility crisis. I've been thinking about what's holding us back from making real progress.Photo by Anirudh on Unsplash The lack of standardization in BCR sequencing data is a major issue Nature.com. This makes it difficult to compare results across different studies and labs. A recent paper highlighted the need for more robust methods for analyzing BCR sequencing data . What caught my eye was the use of machine learning algorithms to improve data quality. This approach has shown promise in other fields, but its application in antibody discovery is still in its infancy . I'm interested in seeing how these methods can be used to identify potential therapeutic antibodies. The use of AI/ML in candidate selection is an area that needs more exploration Nature.com. One of the challenges in using AI/ML for antibody discovery is the need for high-quality training data . This is where FAIR data principles come in - making data findable, accessible, interoperable, and reusable. A recent study demonstrated the importance of FAIR data in antibody discovery Nature.com. Developability is another crucial aspect of antibody discovery . It's not just about finding a potential therapeutic antibody, but also about making sure it can be developed into a viable treatment. I think we need to focus more on developability earlier in the discovery process. What's missing from the current landscape is a more integrated approach to antibody discovery Nature.com. We need to bring together experts from different fields to tackle the reproducibility crisis. I've been thinking about how ENPICOM's IGX Platform can help address some of these challenges. By providing a robust platform for analyzing BCR sequencing data, we can help standardize the field. Working on something similar? I'd love to hear about it — or explore what ENPICOM's IGX Platform can do for your team at enpicom.comReferencesNature.com. "Netrin1 blockade alleviates resistance to chemotherapy in pancreatic cancer" (2026-04-22). LinkNature.com. "Focal white matter lesions drive grey matter inflammation and synapse loss" (2026-04-22). LinkNature.com. "Heart-nosed bat alphacoronaviruses use human CEACAM6 to enter cells" (2026-04-22). Link