SEQ · 005 AI · ANTIBODY · DATA

Notes from the
edge of biology and
machine intelligence.

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5 entries · since 2015

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Nanobodies in silico, rabbits in wet lab, and a mutation-agnostic antibody that skips the JAK2 debate

Antibody discovery is splitting into two cultures. One trusts the model. The other trusts the rabbit. Both had a good month.

VHH Humanization Is Mostly a Search Problem, Not a Grafting Problem

Everyone frames nanobody humanization as CDR grafting. It's not. It's a search problem with a brutal fitness landscape.

Data Governance in Pharma: Notes from the Pistoia Alliance Benelux Forum #5

A speaker-by-speaker recap of the European Life Science Informatics Forum Benelux #5 at GSK Wavre: data governance, FAIR, and agentic AI in drug discovery.

Untar/Unzip Multiple Files in One Command

A quick tip showing how to untar or unzip multiple archive files in one go using find and tar.

Linking Sublime as IDE

Setting up Sublime Text 3 as a default IDE with Jekyll support and Markdown editing.

Sukhi Singh. I build data platforms for antibody discovery.

Currently at ENPICOM, working on software that moves B-cell repertoire data from sequencer to decision. Before that: bioinformatics, pipelines, ontologies, and a lot of FAIR arguments.

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