Nanobodies From a Laptop, BCRs From a Model, and a Mutation-Agnostic Bet
Three signals this month, all pointing at the same thing: antibody discovery is becoming a computational discipline first and a wet-lab one second.
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Nanobodies in silico, rabbits in wet lab, and a mutation-agnostic antibody that skips the JAK2 debate
Antibody discovery is splitting into two cultures. One trusts the model. The other trusts the rabbit. Both had a good month.
VHH Humanization Is Mostly a Search Problem, Not a Grafting Problem
Everyone frames nanobody humanization as CDR grafting. It's not. It's a search problem with a brutal fitness landscape.